Children's Cardiomyopathy Foundation
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NEWS & EVENTS

HEART TO HEART NEWSLETTER
OCTOBER 2013 ISSUE

CCF-Funded Research Studies: Recent Presentations and Publications

Daniela Ciháková, MD, PhD
Johns Hopkins University, Baltimore, MD
Drivers of Pediatric Dilated Cardiomyopathy

Presentations
Wu L, Ong S, Talor MV, Barin JG, Baldeviano GC, Zhang H, Sheikh A, Margolick JB, Kass DA, Iwakura Y, Rose NR and Ciháková D. IL-17A Gives Rise to Proinflammatory and Profibrotic Monocytes by Inducing GM-CSF Production from Cardiac Fibroblasts. Oral and poster presentation at the Association of Medical Laboratory Immunologists Annual Meeting, Savannah, August 2013. Received Doctorate Award for best abstract.

Wu L, Ong S, Talor MV, Barin JG, Baldeviano GC, Zhang H, Sheikh A, Margolick JB, Kass DA, Iwakura Y, Rose NR and Ciháková D. IL-17A Gives Rise to Proinflammatory and Profibrotic Monocytes by Inducing GM-CSF Production from Cardiac Fibroblasts. Poster presentation at the Gordon Research Conference, Phagocytes, Waterville Valley, NH, June 2013

Wu L, Ong S, Talor MV, Barin JG, Baldeviano GC, Zhang H, Sheikh A, Margolick JB, Kass DA, Iwakura Y, Rose NR and Ciháková D. IL-17A Gives Rise to Proinflammatory and Profibrotic Monocytes by Inducing GM-CSF Production from Cardiac Fibroblasts. Poster presentation at Fifteen Annual Pathology Young Investigators' Day, Johns Hopkins University, School of Medicine, Department of Pathology, April 2013.

Publication
Barin JG, Ciháková D. Control of inflammatory heart disease by CD4+ T cells. Annals of the New York Academy of Sciences. 2013 May;1285:80-96.

Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Fairweather D, Bedja D, Stickel NR, LeGault JA, Cardamone AB, Zheng D, Gabrielson KL, Rose NR, Ciháková D. Fatal eosinophilic myocarditis develops in the absence of IFNy and IL17A. Journal of Immunology, 2013.

Ciháková D and Rose NR. Myocarditis and Other Immunological Models of Cardiac Disease. Manual of Research Techniques in Cardiovascular Medicine, Wiley-Blackwell, 2013.

Mark K. Friedberg, MD
Hospital for Sick Children, Toronto, Canada
Patterns and Clinical Significance of Electro-Mechanical
Dyssynchrony in Pediatric Dilated Cardiomyopathy

Presentation
Forsha,D., Slorach,C., Chen,CK., Risum,N., Hornik,C., Sogaard,P.,Mertens,L., Barker,P., Kisslo,J., Friedberg, MK. Classic pattern dyssynchrony is associated with left bundle branch block in pediatric dilated cardiomyopathy. Abstract and oral presentation at the American Heart Association Scientific Sessions, Dallas, TX, Nov 2013

Carmen Sucharov, PhD
University of Colorado, Denver, CO
MicroRNA Expression in Children with Heart Failure

Presentations
Miyamoto, S.D., Peterson, V., Cagle, L., Freed, B., Stauffer, B.L., Sucharov, C.C. Circulating microRNA: Prognostic Biomarker for Pediatric Heart Failure. Oral presentation at the International Society for Heart and Lung Transplantation. Montreal, Canada, April 2013.

Miyamoto, S.D., Peterson, V., Cagle, L., Freed, B., Stauffer, B.L., Sucharov, C.C. Circulating microRNA: Prognostic Biomarker for Pediatric Heart Failure. Poster presentation at the International Society of Heart Research XXI World Congress. San Diego, CA, July 2013.

John Carter Ralphe, MD
University of Wisconsin, Madison, WI
Human iPS Cells and ECT in the Study of Hypertrophic Cardiomyopathy
3D Engineered Cardiac Tissue: A Novel Tool to Unravel
Genotype/Phenotype Relationships in MYBPC3 -
Associated Childhood Hypertrophic Cardiomyopathy

Presentations
De Lange, W.J., Hegge, L., Brost, T., Spring, A., Ralphe, J.C. Heterozygous Expression cMyBP-C E258K Mutation Disrupts Contractile Function in Murine Engineered Cardiac Tissue Model. Abstract and oral presentation at the American Heart Association Scientific Sessions, Dallas, TX, Nov 2013.

De Lange, W., Spring, A., Grimes, A., Hegge, L., Ralphe, J.C. Functional characterization of the cMyBP-C E258K HCM-causing mutation in murine engineered cardiac tissue. Abstract presentation at the International Society for Heart Research-XXI World Congress, San Diego, CA, July 2013.

Publication
De Lange WJ, Grimes AC, Hegge LF, Spring AM, Brost TM, Ralphe JC. E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction. Journal of General Physiology. 2013 Sep;142(3):241-55.

Maria I. Kontaridis, PhD
Beth Israel Deaconess Medical Center, Boston, MA
Developmental Effects of PTPN11 Mutations on
Pediatric Hypertrophic Cardiomyopathy

Presentations
Lauriol, J., Keith, K., Wang, J., Zhang, B., Bronson, R., Lee, K., Kontaridis, M.I. Adult-onset cardiac hypertrophy in LEOPARD Syndrome is caused by both cell autonomous and non-autonomous effects that occur during development. Abstract presenation at the Basic Cardiovascular Society of the American Heart Association Conference, Las Vegas, NV, July 2013.

Awarded Funding
American Heart Association Postdoctoral Fellowship (Jessica Lauriol), Elucidating the role of Shp2 (PTPN11) in endocardial development, 2 year grant: $41,000 (Yr1); $44,000(Yr2)

National Institutes of Health/National Heart Lung and Blood Institute R01 Award (Maria Kontaridis), Elucidating the phosphatase-independent roles of PTPN11 in the heart, 4 year grant: $203, 910 (Yr1), $250,000 (Yr 2-4)

For a listing of other CCF-funded studies, click here.